Twenty-two people were killed and more than 500 injured when a suicide bomber detonated an explosive device as fans were leaving her concert in the city on 22 May last year.
Grande – whose first new music following the attack, No Tears Left To Cry, alluded to the atrocity – spoke about her response to the attack and its impact on her music.
The 24-year-old American singer told Time magazine: “The last thing I would ever want is for my fans to see something like that happen and think it won.
“Music is supposed to be the safest thing in the world. I think that’s why it’s still so heavy on my heart every single day.
“I wish there was more that I could fix. You think with time it’ll become easier to talk about. Or you’ll make peace with it. But every day I wait for that peace to come and it’s still very painful.”
Following the attack, the singer put on a benefit concert in Manchester called One Love Manchester for the families of those affected.
More than £2.7m was raised from the gig which featured Katy Perry, Justin Bieber, Liam Gallagher and The Black Eyed Peas among other A-list acts, and Grande was “moved” after being named an honorary citizen of Manchester.
She also got a bee tattoo, which came to symbolise Manchester’s resilience in the wake of the attack.
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In a message to fans last year, Grande said: “We won’t let hate win. Our response to this violence must be to come closer together, to help each other, to love more, to sing louder, and to live more kindly and generously than we did before.”
Grande’s new album is called Sweetener, with the singer saying the message to her fans was that you can make a bad situation better.