The star, who wrote and played a number of characters in the first three films, has teased that a fourth might be in the works.
Speaking at the premiere of his new thriller Terminal, he said: “Well, I can’t really, I can’t say. But it’s, you know, maybe. It’s a very strong maybe. We’ll see.”
The third film in the popular series – Austin Powers In Goldmember – came out in 2002.
“I would love to,” Myers said of making a fourth. “You know, I’ve been very… I’ve had three kids in the last six years and that’s sort of been where my focus has been.
“But, you know, I love doing all the characters and it’s a non-stop party when we’re shooting. It’s fun.”
His comments come following confirmation that a new Bill and Ted film is in the works after 30 years.
Myers also paid tribute to his Austin Powers co-star Verne Troyer, who played Dr Evil’s sidekick “Mini-Me”.
The 49-year-old died on 21 April.
“Verne’s legacy is that he was a fantastic comedy actor,” Myers said. “And, you know, we wrote it, the part wasn’t much and he made it definitely better than written and we just kept giving him more and more.
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“He was a great stuntman, a great dancer, a great mime and a great human being.
No cause of death was given, but a statement from his family described Troyer as a “fighter” who was unable to overcome a recent bout of adversity, then went on to discuss depression and suicide.