Firefighters from three local stations were called to the family home in Jackson Street, Worsley, at 4.58am this morning and a 14-year-old girl was declared dead at the scene.
An eight-year-old boy and a seven-year-old girl later died in hospital, with another three-year-old girl fighting for her life.
The 35-year-old mother of all four children is also in a serious condition in hospital and a manhunt is under way for a suspect, with Greater Manchester Police “keeping an open mind” as to whether the incident was gang-related.
Greater Manchester Fire and Rescue Service tweeted: “Sadly it’s been confirmed that three children have died following this morning’s house fire in Worsley, another child and a woman are in hospital in a very serious condition. This is a truly tragic incident and all our thoughts go out to the family.”
Sadly it’s been confirmed that three children have died following this morning’s house fire in Worsley, another child and a woman are in hospital in a very serious condition. This is a truly tragic incident and all our thoughts go out to the family ❤️
— Manchester Fire (@manchesterfire) December 11, 2017
Two people managed to escape the blaze before crews arrived.
The incident has been referred to the Independent Police Complaints Commission.
Jackson Street remains closed – with one end blocked by large steel barriers – and firefighters are still at the scene to monitor for any hot spots.
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Forensic investigators are also in attendance.