The Met Office has issued a yellow warning for heavy rain and strong winds across much of eastern, southeastern and central England.
Meteorologists are predicting spray and flooding could lead to difficult driving conditions and some road closures.
Trains and buses could also be affected with the Met Office warning of possible delays or cancellations.
It also said there was a “small chance” homes and businesses could be flooded as a result of the rain.
“The heavy rain will be accompanied by strong to gale force northerly winds and it may be cold enough to produce some snow on high ground although this seems unlikely to settle,” the Met Office wrote on its website.
Temperatures will struggle to rise above 5C (41F) in the South East and East on Monday with some places possibly seeing up to 70mm of rain and possibly wet snow on higher hills.
Winds from the north will be “unusually strong and gusty” reaching 40mph to 50mph inland in those areas and in the East Midlands and possibly 60mph along the coasts.
Sky News Weather Presenter Isobel Lang warned of “Monday misery” for the areas affected with “persistent, heavy rain and strong cold winds with temperatures stuck at only 5C (41F) or 6C (42.8F)”.
She said the gusts could cause disruption to flights.
“The April average for rainfall in southeast England is around 50mm so there will be some places that top that within 24 hours, so that’s we’re concerned,” she said.
“It’s unusually cold, wet and windy for this time of the year, there will be some very difficult driving conditions and disruptions at airports with the strong northerly winds.
“We are expecting impacts from this type of weather – once it arrives, it’s stuck with us all day.”
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In contrast, much of Scotland and Northern Ireland are expected to be sunny with warmer temperatures.
At present, the weather is expected to perk up for the bank holiday weekend with highs of up to 18C (64.4F) on Saturday.