Wasps fly-half Danny Cipriani has been included in a 34-man England squad for the tour of South Africa in June.
Owen Farrell has been named captain with hooker Dylan Hartley unavailable.
There are eight uncapped players in Eddie Jones’ squad including Sale back Cameron Redpath, Wasps flanker Jack Willis and New Zealand-born flanker Brad Shields.
Experienced players such as scrum-half Danny Care and Lions tourists Dan Cole and James Haskell have been rested.
Scott Wisemantel, who worked with Jones at Australia and Japan, has been brought in as an attack coach for the tour.
Jones said the tour would be England’s “most exciting challenge for us as a group since 2016”.
He added: “We have an opportunity to create some history next month and win the Test series, something no England side has done before [in South Africa].
“There are a number of players out injured or not selected so it provides a big opportunity for others.
“We will need to be physically aggressive and tactically smart against the Springboks who we know will be combative and reinvigorated by their new coaching set-up.”
More to follow.
England squad to tour South Africa:
Backs: Mike Brown (Harlequins), Elliot Daly (Wasps), Nathan Earle (Saracens)*, Jonny May (Leicester Tigers), Denny Solomona (Sale Sharks), Danny Cipriani (Wasps), OwenFarrell (Saracens), George Ford (Leicester Tigers), Alex Lozowski (Saracens), Cameron Redpath (Sale Sharks)*, Dan Robson (Wasps)*, Henry Slade (Exeter Chiefs), Ben Spencer (Saracens)*, Ben Te’o (Worcester Warriors), Ben Youngs (Leicester Tigers)
Forwards: Tom Curry (Sale Sharks), Ben Earl (Saracens)*, Jonny Hill (Exeter Chiefs)*, Nick Isiekwe (Saracens), Maro Itoje (Saracens), Joe Launchbury (Wasps), Chris Robshaw (Harlequins), Brad Shields (Hurricanes/Wasps)*, Sam Simmonds (Exeter Chiefs), Billy Vunipola (Saracens), Jack Willis (Wasps)*, Mark Wilson (Newcastle), Luke Cowan-Dickie (Exeter Chiefs), Ellis Genge (Leicester Tigers), Jamie George (Saracens), Joe Marler (Harlequins), Kyle Sinckler (Harlequins), Mako Vunipola (Saracens), Harry Williams (Exeter Chiefs)
Not considered for selection:
Backs: Danny Care (Harlequins), Jonathan Joseph (Bath Rugby), Harry Mallinder (Northampton Saints), Joe Marchant (Harlequins), Jack Nowell (Exeter Chiefs), Semesa Rokoduguni (Bath Rugby), Manu Tuilagi (Leicester Tigers), Anthony Watson (Bath Rugby), Richard Wigglesworth (Saracens)
Forwards: Jack Clifford (Harlequins), Dan Cole (Leicester Tigers), Tom Dunn (Bath Rugby), Charlie Ewels (Bath Rugby), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Nathan Hughes (Wasps), George Kruis (Saracens), Courtney Lawes (Northampton Saints), Will Spencer (Worcester Warriors), Sam Underhill (Bath Rugby)